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Severe Acute Hepatitis of Unknown Cause in Children: A 2-Year Single-Center Experience
Hasret Ayyıldız Civan1, Ferhat Sarı1
1Istanbul Aydın University, Florya VM Medical Park Application and Research Hospital. Organ Transplantation Center.
Objective:
The study aimed to retrospectively evaluate the demographic characteristics, presenting complaints, and etiologies of pediatric patients hospitalized with a diagnosis of severe acute hepatitis in the last 2 years in our institution.
Methods:
Between July 1, 2022, and July 1, 2024, 9 patients with a diagnosis of probable severe acute hepatitis who were considered candidates for liver transplantation were included. Informed consent was obtained from the families.
Results:
The mean Glasgow Coma Scale score at presentation was 11 (range: 4-15). Severe acute hepatitis is an urgent condition with rapid progression, potential for multiorgan failure, unpredictable course, and possible severe complications, often requiring liver transplantation. Patients are managed with a multidisciplinary approach including pediatric intensive care, pediatric gastroenterology, and the organ transplant unit.
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