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Temporal mapping of epithelial vs. immune cell inflammatory shifts in the neonatal intestinal mucosa

Aparna Venkatraman1,2, John M Perry3,4,5, Venkatesh Sampath6

  • 1Department of Pediatrics, Division of Neonatology, Children's Mercy Kansas City, Kansas City, MO, USA.

Pediatric Research
|October 17, 2025
PubMed
Abstract

No abstract available in PubMed .

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Renewal of Intestinal Stem Cells01:23

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...

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