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Method for the Assessment of Effects of a Range of Wavelengths and Intensities of Red/near-infrared Light Therapy on Oxidative Stress In Vitro
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Lights-on for Cardiovascular Disease: Can Red and Near Infrared Light Treatment Help the Recovery Process?

Gilles Barone-Rochette1,2,3,4, Lucile Cochard1, Malvina Billeres1

  • 1Université Grenoble AlpesFonds Clinatec, Grenoble, France.

Annals of Biomedical Engineering
|October 17, 2025
PubMed
Summary

Photobiomodulation, or light treatment, shows promise in improving recovery after heart attack and stroke by reducing inflammation and improving blood flow. Further large-scale clinical studies are needed to confirm its effectiveness.

Keywords:
Cell deathInfarctionMitochondriaPhotobiomodulationStroke

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Area of Science:

  • Cardiovascular Disease Research
  • Regenerative Medicine
  • Biomedical Engineering

Background:

  • Acute myocardial infarction and stroke are leading causes of death with limited recovery options.
  • Both conditions result from compromised blood flow, leading to cell death in the heart and brain.
  • Current treatment options for the recovery phase are insufficient.

Purpose of the Study:

  • To review the effectiveness of photobiomodulation (red and near-infrared light) in improving recovery after myocardial infarction and stroke.
  • To analyze findings from preclinical and clinical studies on light treatment for these conditions.
  • To identify research gaps and future directions for photobiomodulation therapy.

Main Methods:

  • Narrative review of preclinical (animal models) and clinical studies on photobiomodulation for myocardial infarction and stroke.
  • Analysis of how light treatment impacts key pathological hallmarks like inflammation, infarct size, and mitochondrial activity.
  • Evaluation of existing clinical trial methodologies and data quality.

Main Results:

  • Preclinical studies demonstrate that light treatment reduces infarct size, inflammation, and improves reperfusion by stimulating mitochondrial activity.
  • Clinical evidence for acute myocardial infarction is limited to two small, short-term studies.
  • Clinical trials for stroke have methodological limitations, requiring further investigation.

Conclusions:

  • Photobiomodulation shows potential as a therapeutic strategy for improving recovery from myocardial infarction and stroke.
  • There is a critical need for large-scale, placebo-controlled clinical trials to validate these findings.
  • Development of novel devices for targeted light delivery to the heart and brain is promising.