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DNA methylation alterations in acute lymphoblastic leukemia survivors with late neurocognitive deficits

Sarah J Goodman1, Darci T Butcher2, Sharon L Guger3

  • 1Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada.

Leukemia
|October 17, 2025
PubMed
Abstract

No abstract available in PubMed .

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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