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Related Concept Videos

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  3. Dedicated Drug-eluting Stents Versus Bare-metal Stents For Vertebral Artery Origin Stenosis: A Real-world Single-center Experience.
  1. Home
  3. Dedicated Drug-eluting Stents Versus Bare-metal Stents For Vertebral Artery Origin Stenosis: A Real-world Single-center Experience.

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Dedicated drug-eluting stents versus bare-metal stents for vertebral artery origin stenosis: a real-world

Xiaoxin Sun1, Lei Wang1, Rui Zhu1

  • 1Department of Neurology, Beijing Geriatric Hospital, Beijing, China.

BMC Neurology
|October 17, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Dedicated drug-eluting stents (DES) significantly reduced in-stent restenosis (ISR) after vertebral artery stenting compared to bare metal stents (BMS). Safety outcomes were comparable, though stent fracture requires further study.

Keywords:
AngioplastyDrug-eluting stentIn-stent restenosisProspective cohort studyVertebral artery stenosis

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Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • In-stent restenosis (ISR) is a significant complication following vertebral artery origin (VAO) stenting.
  • Dedicated rapamycin-eluting stents (DES) have been developed for vertebral artery applications.
  • This study compares the efficacy and safety of dedicated DES versus bare metal stents (BMS) for VAO lesions.

Purpose of the Study:

  • To evaluate the effectiveness of dedicated DES in reducing ISR compared to BMS.
  • To assess the safety profile of dedicated DES versus BMS in patients with symptomatic severe VAOS.
  • To investigate secondary endpoints including stroke, symptomatic ISR, mortality, and stent fracture.

Main Methods:

  • An observational prospective, single-center cohort study enrolled 217 patients with symptomatic severe VAOS.
  • Patients received either dedicated DES (n=150) or BMS (n=67) between January 2021 and December 2023.
  • Primary endpoints were 1-year ISR rate and 30-day stroke/death; secondary endpoints included stroke, symptomatic ISR, mortality, and stent fracture.

    • Main Results:

    • Dedicated DES showed significantly lower 1-year ISR rates (9.3% vs. 37.3%; p < 0.001), a 75.1% relative risk reduction compared to BMS.
    • No significant differences in 30-day stroke/death or 31-day to 1-year stroke were observed between groups.
    • Symptomatic ISR occurred only in the BMS group (2.6%); stent fracture rates were numerically higher in the DES group (8.7% vs. 4.5%).

    Conclusions:

    • Rapamycin-eluting vertebral artery stents significantly reduce ISR rates compared to BMS in symptomatic severe VAOS.
    • Dedicated DES demonstrated comparable short- and mid-term safety profiles to BMS.
    • Stent fracture may modulate ISR risk and warrants further investigation.