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Insight into the mechanisms and dysregulation of KMT5C-H4K20me3 in cancer

Jihye Son1,2, Andrea L Kasinski1,2

  • 1Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.

Epigenetics
|October 18, 2025
PubMed

Insights

KMT5C-mediated histone H4 lysine 20 trimethylation (H4K20me3) is crucial for genome integrity but also implicated in cancer. This review explores its role in cancer and potential new therapeutic strategies.

Area of Science:

  • Epigenetics and Gene Regulation
  • Cancer Biology
  • Molecular Oncology

Background:

  • Histone H4 lysine 20 trimethylation (H4K20me3) mediated by KMT5C is traditionally associated with heterochromatin and genome stability.
  • Recent studies link KMT5C-H4K20me3 dysregulation to various cancers, highlighting its therapeutic potential.
  • The exact mechanisms of KMT5C recruitment and gene regulation are not fully understood.

Purpose of the Study:

  • To review the role of KMT5C-mediated H4K20me3 in cancer.
  • To provide a comprehensive overview of KMT5C functions and dysregulation in oncogenesis.
  • To highlight novel findings and potential therapeutic interventions.

Main Methods:

  • Literature review of existing studies on KMT5C and H4K20me3.
  • Analysis of emerging evidence on KMT5C's role in cancer.
  • Synthesis of current knowledge on H4K20me3 deposition pathways.

Main Results:

  • KMT5C-H4K20me3 is implicated in cancer development and progression.
  • A novel, non-canonical pathway for H4K20me3 deposition by KMT5C is suggested.
  • KMT5C presents a potential target for anti-cancer therapies.

Conclusions:

  • KMT5C-mediated H4K20me3 plays a dual role in genome integrity and cancer.
  • Further research into KMT5C recruitment and regulation is needed.
  • Exploration of KMT5C as a therapeutic target offers promising avenues for cancer treatment.
Keywords:
H4K20me3KMT5CSUV420H2cancerepigenetics

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