Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

770
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
770
Aging01:26

Aging

587
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
587
Longitudinal Research02:20

Longitudinal Research

13.1K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.1K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.3K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.3K
Telomeres and Telomerase02:41

Telomeres and Telomerase

7.0K
7.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Herbal Polyphenolic Mixtures as Antioxidant and Cytoprotective Agents in Respiratory Diseases: Molecular Mechanisms and Therapeutic Perspectives.

International journal of molecular sciences·2026
Same author

Heritability of Alzheimer's disease-related plasma biomarkers in the Amish population.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Uncovering lipid biomarkers linked to methylphenidate efficacy in treating apathy in Alzheimer's disease: insights from the ADMET 2 trial.

Alzheimer's research & therapy·2026
Same author

Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Shared Genetic Architecture Between Kidney Function and Alzheimer Disease Across Ancestries.

medRxiv : the preprint server for health sciences·2026
Same author

Disrupted lipid homeostasis as a pathogenic mechanism in ABCA7-associated Alzheimer's disease risk.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Related Experiment Video

Updated: Jan 14, 2026

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

47.3K

Telomere length, aging, and cognitive function in the Midwestern Amish.

Yining Liu1, Yeunjoo E Song1, Audrey Lynn2

  • 1Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

HGG Advances
|October 18, 2025
PubMed
Summary

Telomere length (TL) is linked to aging but not cognitive function in the Amish. This study examined TL and cognition in a unique population, finding no association but identifying new genetic links to TL.

Keywords:
AmishGWASPGDagingcognitive functionfounder populationheritabilitytelomere lengthwhole-genome sequencing

More Related Videos

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.1K
Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
11:44

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

Published on: March 22, 2024

2.9K

Related Experiment Videos

Last Updated: Jan 14, 2026

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

47.3K
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.1K
Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
11:44

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

Published on: March 22, 2024

2.9K

Area of Science:

  • Genetics
  • Aging Research
  • Neuroscience

Background:

  • Telomere length (TL) is a biomarker for biological aging.
  • The association between TL and cognitive function, including Alzheimer's disease (AD), is debated.
  • Genetic and environmental factors complicate TL-cognition relationship studies.

Purpose of the Study:

  • To investigate the relationship between DNA sequence-determined TL and cognitive function.
  • To leverage the unique genetic homogeneity of the Midwestern Amish population to reduce confounding factors.
  • To identify genetic loci associated with TL.

Main Methods:

  • Comprehensive characterization of DNA sequence-determined TL.
  • Analysis of TL association with cognitive function in the Midwestern Amish cohort.
  • SNP-based and pedigree-based heritability estimation of TL.
  • Genome-wide association study (GWAS) for TL loci identification.

Main Results:

  • Confirmed expected telomere shortening with age.
  • No significant correlation was found between TL and cognitive function in this population.
  • Identified three novel loci associated with TL through GWAS.
  • These loci contained Amish-enriched rare variants.

Conclusions:

  • The study found no association between telomere length and cognitive function in the Midwestern Amish.
  • The unique population structure facilitated robust heritability estimates and GWAS.
  • New genetic loci influencing TL were discovered, highlighting the role of rare variants.