Superficial Perivascular Dermatitis With Eosinophils: A Diagnostic Challenge in a Patient With Autoimmune Disease

Superficial perivascular dermatitis with tissue eosinophils is a histopathologic finding associated with various dermatologic conditions, including urticarial dermatitis, drug reactions, autoimmune processes, and infectious etiologies. Diagnosis often requires correlation of clinical findings, laboratory evaluations, and histopathologic examination. We present a case of a 24-year-old female with urticarial dermatitis-like symptoms, whose final diagnosis of superficial perivascular dermatitis with tissue eosinophils was established 2 weeks postdischarge. The case highlights the importance of maintaining a broad differential diagnosis, employing a structured diagnostic approach, and implementing strategic follow-up when histopathologic findings are delayed. This delay highlights the importance of a thorough differential diagnosis, a structured diagnostic approach, and strategic follow-up to guide management and allow for appropriate treatment options. Potential etiologies are explored, including medication-induced reactions, and a diagnostic approach is proposed for future cases.