Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Regulation01:25

Drug Regulation

2.7K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
2.7K
ortho–para-Directing Deactivators: Halogens01:24

ortho–para-Directing Deactivators: Halogens

6.6K
Halogens are ortho–para directors. They are more electronegative than carbon. Therefore, as ring substituents, they can withdraw electrons through the inductive effect and deactivate the aromatic ring towards electrophilic substitution. Halogens also have an electron-donating resonance effect on the ring, which influences the orientation of the incoming electrophile. If an electrophile attacks at the ortho or the para position, the halogen donates electrons and stabilizes the intermediate...
6.6K
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

751
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
751
Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers01:20

Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers

1.5K
Class IV antiarrhythmic drugs, such as verapamil and diltiazem, block calcium channels. They primarily affect the heart, slowing the conduction in calcium-dependent tissues like the SA and AV nodes. These drugs manage reentrant supraventricular tachycardia (SVT) and reduce ventricular rate in atrial flutter/fibrillation.
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...
1.5K
Adrenergic Antagonists: Chemistry and Classification of ɑ-Receptor Blockers01:17

Adrenergic Antagonists: Chemistry and Classification of ɑ-Receptor Blockers

1.5K
Adrenergic antagonists, or sympatholytics, inhibit adrenoceptor activation driven by catecholamines or agonists. Based on their adrenoceptor specificity, adrenergic blockers can be categorized into two primary groups: α-adrenergic blockers (α-blockers) and β-adrenergic blockers (β-blockers). α-blockers interact with α1 and α2 subtypes of α-adrenoceptors.
Nonselective α-blockers: Nonselective α-blockers contain haloalkylamine or imidazoline...
1.5K
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

2.1K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Advancing a Global Oral Health Research Agenda.

Journal of dental research·2026
Same author

The IADR Policy and Position Statements on Safety of Dental Amalgam.

Journal of dental research·2026
Same author

Cost-Effectiveness of Sealant Placement on Molars in Young Adults in the United States.

JDR clinical and translational research·2026
Same author

Temporal <i>In Vitro</i> Models of Skin Wound Healing Components: A Cell-Specific Framework for Acute and Chronic Repair Mechanisms.

Advances in wound care·2026
Same author

Co-infection with Cbp<sup>+</sup> <i>Streptococcus mutans</i> and <i>Candida albicans</i> is associated with root caries in older adults.

Journal of oral microbiology·2026
Same author

In vitro Assessment of Open-Access Digital Workflow for Presurgical Nasoalveolar Molding in Unilateral Cleft Lip and Palate.

Clinical, cosmetic and investigational dentistry·2026
Same journal

Oral Burden of Sjögren Disease: A Systematic Review and Meta-analysis.

Journal of dental research·2026
Same journal

Gingival Fibroblast-Driven Osteoimmunology via the IL-33-ILC2-IL-13 Axis.

Journal of dental research·2026
Same journal

YAP/TAZ Drive Oral Leukoplakia Progression and Confer Ferroptosis Vulnerability.

Journal of dental research·2026
Same journal

Multiancestral GWAS of Dental Malocclusion Identifies Multiple Risk Loci.

Journal of dental research·2026
Same journal

Corrigendum to Redistribution Effect of Demineralized Dentin on Hydrophobic Monomers.

Journal of dental research·2026
See all related articles

Related Experiment Video

Updated: Jan 14, 2026

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
08:12

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

10.6K

The AADOCR Position Statement on Topical Fluoride.

P R Arany1, M Charles-Ayinde2, M Fontana3

  • 1School of Dental Medicine, University at Buffalo, Buffalo, NY, USA.

Journal of Dental Research
|October 18, 2025
PubMed
Summary
This summary is machine-generated.

Topical fluorides are essential for preventing and managing dental caries. Recommendations include daily use of fluoride toothpaste, with specific amounts for children to prevent fluorosis.

Keywords:
caries treatmentdental cariesdental public healthfluoride(s)public healthtreatment planning

More Related Videos

Semi-Automated Planimetric Quantification of Dental Plaque Using an Intraoral Fluorescence Camera
09:34

Semi-Automated Planimetric Quantification of Dental Plaque Using an Intraoral Fluorescence Camera

Published on: January 27, 2023

2.4K
Detection and Removal of Tooth-Colored Composite Resin Using the Fluorescence-Aided Identification Technique
05:42

Detection and Removal of Tooth-Colored Composite Resin Using the Fluorescence-Aided Identification Technique

Published on: July 27, 2022

4.3K

Related Experiment Videos

Last Updated: Jan 14, 2026

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
08:12

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

10.6K
Semi-Automated Planimetric Quantification of Dental Plaque Using an Intraoral Fluorescence Camera
09:34

Semi-Automated Planimetric Quantification of Dental Plaque Using an Intraoral Fluorescence Camera

Published on: January 27, 2023

2.4K
Detection and Removal of Tooth-Colored Composite Resin Using the Fluorescence-Aided Identification Technique
05:42

Detection and Removal of Tooth-Colored Composite Resin Using the Fluorescence-Aided Identification Technique

Published on: July 27, 2022

4.3K

Area of Science:

  • Dental Research
  • Public Health
  • Fluoride Chemistry

Background:

  • Topical fluorides are crucial for dental caries prevention and management.
  • Understanding fluorapatite's acid resistance and fluoride's antimicrobial effects solidifies its role in caries control.

Purpose of the Study:

  • To summarize current evidence-based recommendations for topical fluoride use in caries management.
  • To provide guidance on appropriate fluoride concentrations and application methods for different age groups and risk levels.

Main Methods:

  • Review of current scientific evidence and clinical guidelines.
  • Analysis of recommendations from the American Association for Dental, Oral, and Craniofacial Research (AADOCR).

Main Results:

  • AADOCR recommends 1,000-1,500 ppm fluoride toothpaste twice daily.
  • For young children, a rice-grain-sized smear minimizes fluorosis risk.
  • High-risk patients may benefit from professional applications and adjunct therapies.

Conclusions:

  • Topical fluoride use is a cornerstone of evidence-based oral health.
  • Guidelines emphasize individualized risk assessment and appropriate fluoride modalities.
  • Continued research is vital for refining topical fluoride recommendations.