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Mussel-Inspired Etchant with Catechol-Lys-Methacrylate for Bond Durability.

Y T Hu1,2, C Y Yang3,4, D J Wang1,2

  • 1Department of Oral Surgery, 920th Hospital of Joint Logistics Support Force, PLA, Teaching Hospital of Kunming Medical University, Kunming, China.

Journal of Dental Research
|October 18, 2025
PubMed
Summary

This study introduces catechol-lysine-methacrylate (CLM) to improve dental bonding by managing moisture and stabilizing collagen. CLM-functionalized etchants enhance resin infiltration and long-term bond durability in tooth restorations.

Keywords:
acid etchantadhesivecrosslinking reagentsdentinhybrid layermoisture

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Area of Science:

  • Biomaterials Science
  • Dental Materials
  • Adhesion Science

Background:

  • Resin-dentin bonding is crucial for tooth restoration.
  • Inadequate moisture control at the bonding interface creates a defect zone, challenging restoration longevity.

Purpose of the Study:

  • To develop a novel functionalized etchant using mussel-inspired wet-adhesion mechanisms.
  • To improve moisture control and collagen stability at the resin-dentin interface for enhanced bonding durability.

Main Methods:

  • Functionalized phosphoric acid etchants with catechol-lysine-methacrylate (CLM).
  • Confirmed catechol binding, validated lysine's water release role, and assessed resin infiltration using microscopy.
  • Evaluated collagen stabilization via bond strength tests, enzyme inhibition assays, and thermal cycling.

Main Results:

  • Catechol binding to demineralized dentin and enhanced resin tag lengths were observed.
  • CLM facilitated rapid water release and demonstrated collagen stabilization through Schiff base/ester bonds.
  • CLM-treated groups maintained bond strength after 10,000 thermal cycles, particularly at 4-5 mg/mL concentrations.

Conclusions:

  • CLM-functionalized etchants improve moisture control and collagen stability at the resin-dentin interface.
  • This approach enhances resin infiltration and long-term bonding durability in vitro.
  • CLM represents a promising strategy for developing more robust dental restorative materials.