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Mussel-Inspired Etchant with Catechol-Lys-Methacrylate for Bond Durability
Y T Hu1,2, C Y Yang3,4, D J Wang1,2
1Department of Oral Surgery, 920th Hospital of Joint Logistics Support Force, PLA, Teaching Hospital of Kunming Medical University, Kunming, China.
Journal of Dental Research
|October 18, 2025
Summary
This study introduces catechol-lysine-methacrylate (CLM) to improve dental bonding by managing moisture and stabilizing collagen. CLM-functionalized etchants enhance resin infiltration and long-term bond durability in tooth restorations.
Area of Science:
- Biomaterials Science
- Dental Materials
- Adhesion Science
Background:
- Resin-dentin bonding is crucial for tooth restoration.
- Inadequate moisture control at the bonding interface creates a defect zone, challenging restoration longevity.
Purpose of the Study:
- To develop a novel functionalized etchant using mussel-inspired wet-adhesion mechanisms.
- To improve moisture control and collagen stability at the resin-dentin interface for enhanced bonding durability.
Main Methods:
- Functionalized phosphoric acid etchants with catechol-lysine-methacrylate (CLM).
- Confirmed catechol binding, validated lysine's water release role, and assessed resin infiltration using microscopy.
- Evaluated collagen stabilization via bond strength tests, enzyme inhibition assays, and thermal cycling.
Main Results:
- Catechol binding to demineralized dentin and enhanced resin tag lengths were observed.
- CLM facilitated rapid water release and demonstrated collagen stabilization through Schiff base/ester bonds.
- CLM-treated groups maintained bond strength after 10,000 thermal cycles, particularly at 4-5 mg/mL concentrations.
Conclusions:
- CLM-functionalized etchants improve moisture control and collagen stability at the resin-dentin interface.
- This approach enhances resin infiltration and long-term bonding durability in vitro.
- CLM represents a promising strategy for developing more robust dental restorative materials.
