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Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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Evisceration of Mouse Vitreous and Retina for Proteomic Analyses
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Retinal microstructual and microvascular changes in mucopolysaccharidoses.

Lucas Wipprecht1,2, Anna J Borchers3, Julia V Stingl3

  • 1Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University of Mainz, Mainz, Germany. lwipprec@students.uni-mainz.de.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|October 18, 2025
PubMed
Summary
This summary is machine-generated.

Mucopolysaccharidoses (MPS) patients show significant vision impairment, including reduced visual acuity and visual fields, along with higher intraocular pressure (IOP). This study reveals microstructural and microvascular damage in the optic disc and retina of MPS patients compared to controls.

Keywords:
High magnification moduleMucopolysaccharidosesOptical coherence tomographyOptical coherence tomography angiographyRetinopathy

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Area of Science:

  • Ophthalmology
  • Genetics
  • Metabolic Disorders

Background:

  • Mucopolysaccharidoses (MPS) are rare genetic disorders.
  • Ocular manifestations are common in MPS, impacting vision.
  • Posterior segment involvement requires detailed investigation.

Purpose of the Study:

  • To analyze ocular manifestations in the posterior segment of the eye in MPS patients.
  • To specifically investigate retinal and optic disc pathologies.
  • To compare findings in MPS patients with healthy controls.

Main Methods:

  • Prospective study of 29 MPS patients and 29 age/gender-matched healthy controls.
  • Comprehensive eye examinations including visual acuity, IOP, visual fields, funduscopy.
  • Advanced imaging techniques: Spectral-Domain Optical Coherence Tomography (SD-OCT), OCT-Angiography (OCT-A), and High Magnification Module (HMM).

Main Results:

  • MPS patients had significantly worse visual acuity (p<0.001) and higher IOP (p<0.001).
  • Retinal findings included optic disc atrophy, macular atrophy, and pigmentary retinopathy, particularly in MPS II.
  • Reduced retinal thickness and capillary density were observed in MPS patients, correlated with IOP.

Conclusions:

  • MPS patients exhibit significant visual impairment and elevated IOP.
  • Microstructural and microvascular alterations in the optic disc and retina are characteristic of MPS.
  • Early detection and monitoring of posterior segment changes are crucial for MPS management.