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Zebrafish: A Versatile and Powerful Model for Biomedical Research.

Sundus Siddiqui1, Hiba Siddiqui1, Emna Riguene1

  • 1College of Medicine, QU Health, Qatar University, Doha, Qatar.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|October 18, 2025
PubMed
Summary

Zebrafish (Danio rerio) are a powerful model for precision medicine, aiding disease research and personalized therapies. Advances in gene editing and imaging enhance their role in understanding human health and disease.

Keywords:
animal modelbiomedical researchhuman diseasemodel organismzebrafish

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Area of Science:

  • * Comparative genomics and developmental biology
  • * Translational medicine and disease modeling
  • * Bioinformatics and computational biology

Background:

  • * Zebrafish (Danio rerio) offer unique advantages for biomedical research, including optical transparency and rapid development.
  • * High genetic similarity to humans facilitates the study of conserved biological processes and diseases.
  • * Established use in cardiovascular, neurological, metabolic, oncological, and infectious disease research.

Purpose of the Study:

  • * To highlight the expanding utility of zebrafish in precision medicine.
  • * To discuss novel applications and emerging technologies enhancing zebrafish models.
  • * To underscore the translational relevance of zebrafish research for human health.

Main Methods:

  • * CRISPR/Cas9, prime editing, and morpholino technologies for genetic manipulation.
  • * Real-time imaging and high-throughput screening.
  • * Integration of single-cell transcriptomics, computational modeling, and machine learning.

Main Results:

  • * Expanded applications in larval urine assays, rare variant validation, host-microbiome studies, and behavioral profiling.
  • * Overcoming limitations through advanced omics and computational approaches.
  • * Demonstrated scalability and power for disease modeling and therapeutic strategy development.

Conclusions:

  • * Zebrafish are a versatile and increasingly relevant model for precision medicine.
  • * Technological advancements are enhancing their translational impact.
  • * Zebrafish platforms are crucial for developing personalized therapeutic strategies.