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Gold-Decorated Upconversion Luminescent Nanozyme Enables ROS-Responsive Antioxidant for Myocardial Injury Repair.

Yuemei Li1, Yongmei Li2

  • 1Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Fujian Branch of National Clinical Research Center for Cardiovascular Diseases, Xiamen, China, No. 2999 Jinshan Road, Huli District, Xiamen, Fujian 361004, P.R. China.

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Summary
This summary is machine-generated.

This study introduces novel Yb/Er/CeOF@SiO2@Au upconversion nanoparticles (UCNPs) as a potent nanozyme. These UCNPs effectively scavenge reactive oxygen species (ROS), offering a promising therapeutic strategy for heart diseases and cardiac injuries.

Keywords:
Yb/Er/CeOF@SiO2@Aucatalytic ROSmyocardial damagenanozymeupconversion luminescence imaging

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Cardiovascular Research

Background:

  • Reactive oxygen species (ROS) play a critical role in heart diseases.
  • Developing stable and effective nanozymes for cardiac injury treatment is challenging.
  • Upconversion nanoparticles (UCNPs) offer potential for ROS catalysis.

Purpose of the Study:

  • To design and synthesize novel Yb/Er/CeOF@SiO2@Au upconversion nanoparticles (UCNPs) for ROS catalysis.
  • To evaluate the efficacy of these UCNPs in protecting heart cells from oxidative injury.
  • To explore the therapeutic potential of UCNPs in treating cardiac injuries.

Main Methods:

  • Synthesis of Yb/Er/CeOF@SiO2@Au UCNPs.
  • Investigation of multienzyme mimicry (superoxide dismutase, glutathione peroxidase).
  • In vitro and in vivo evaluation of UCNPs in H2O2 and LPS-induced myocardial damage models.

Main Results:

  • Yb/Er/CeOF@SiO2@Au UCNPs demonstrated efficient ROS scavenging capabilities.
  • UCNPs exhibited versatile multienzyme mimicry and stable fluorescence.
  • Effective treatment of myocardial damage, improved mitochondrial function, and reduced biotoxicity were observed in vitro and in vivo.

Conclusions:

  • Yb/Er/CeOF@SiO2@Au UCNPs represent a novel nanozyme with significant potential for cardiovascular disease therapeutics.
  • The developed UCNPs offer a promising strategy for treating oxidative stress-related heart conditions.
  • This work highlights the therapeutic advantages of UCNPs in managing cardiac injuries.