Higher dietary ketogenic ratio is associated with accelerated biological aging among US adults: analysis from NHANES
Xinyi Zheng1, Hongyang Gong2, Ruimin Zhang3
1School of Medicine, Nankai University, Tianjin, China; Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for the Preventionand Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine(zyyzdxk-2023310), Beijing, China.
Abstract:
Ketogenic diet (KD) is widely prescribed for weight management in obese individuals, yet their potential impact on biological aging remains unclear. Using cross-sectional data from the National Health and Nutrition Examination Survey (NHANES, 2005-2018) to test the hypothesis that KD may accelerate biological aging, biological aging was assessed through 4 indices: biological age acceleration (BioAgeAccel), phenotypic age acceleration (PhenoAgeAccel), homeostatic dysregulation (HD) and serum Klotho concentrations. Weighted multivariable linear regression and restricted cubic spline analyses were performed to evaluate the effects of KD on biological aging. Subgroup and interaction analyses were performed to assess the consistency of these associations across populations. Among the 22,026 included adults, fully adjusted models revealed that each 1-unit increase in dietary ketogenic ratio (DKR) corresponded to a 5.65-year increase in BioAgeAccel (P < .001), a 0.88-year increase in PhenoAgeAccel (P < .05), and a 67.67 pg/mL decrease in Klotho concentrations (P < .05). Restricted cubic spline (RCS) revealed a linear positive association between BioAgeAccel and DKR (P for overall < .001, P for nonlinear = .257), a positive association with potential nonlinearity between PhenoAgeAccel and DKR (P for overall = .001, P for nonlinear = .089, Inflection point = .371), a positive association with nonlinearity (P for overall = .016, P for overall = .002, Inflection point = .371) between HD and DKR, and a negative association with a nonlinear trend (P for overall = .002, P for nonlinear = .053, Inflection point = .374) between Klotho and DKR. Subgroup and interaction analyses confirmed the consistency of these associations across populations. Higher DKR values are positively correlated with accelerated biological aging, particularly when DKR exceeds 0.371. This is the first population-based study to demonstrate this association.
More Related Videos
08:52Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
Published on: April 6, 2022
07:25Long-Term Culture of Individual Caenorhabditis elegans on Solid Media for Longitudinal Fluorescence Monitoring and Aversive Interventions
Published on: December 2, 2022
Related Concept Videos
Pharmacodynamics in Geriatric Patients: Effects of Age
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Pharmacokinetics in Pediatric Patients: Drug Metabolism
