Related Experiment Video
Updated: Jan 6, 2026
06:04
Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
Published on: August 8, 2025
473
Chronic Conditions and Patient-Centered Outcomes After Transcatheter Aortic Valve Intervention
Benjamin S Wessler1, Amanda Stebbins2, Mohamad Alkhouli3
1Division of Cardiology, Cardiovascular Center at Tufts Medical Center, Boston, Massachusetts, USA.
JACC. Advances
|October 18, 2025
Summary
Transcatheter aortic valve intervention (TAVI) improves quality of life for patients with aortic stenosis, even those with multiple chronic conditions (MCCs). While MCCs are linked to higher mortality, TAVI still offers significant health gains and survival benefits.
Area of Science:
- Cardiology
- Geriatrics
- Palliative Care
Background:
- Transcatheter aortic valve intervention (TAVI) has transformed care for elderly individuals with aortic stenosis.
- The impact of multiple chronic conditions (MCCs) on TAVI outcomes requires further investigation.
Purpose of the Study:
- To analyze the association between chronic conditions and patient outcomes following TAVI.
- To determine the utilization rates of palliative care services in TAVI patients.
Main Methods:
- A cohort study utilized the STS/ACC TTVT registry linked with CMS claims data.
- Patients undergoing TAVI were assessed for MCCs in the year prior to the procedure.
- Multivariable logistic regression analyzed the relationship between chronic conditions and outcomes.
Main Results:
- 188,629 TAVI procedures were analyzed; the median age was 82 years.
- MCCs were associated with increased 1-year mortality (aHR: 2.33) and lower baseline quality of life.
- Quality of life improvements post-TAVI were substantial and independent of chronic disease burden.
Conclusions:
- Chronic conditions are linked to poorer survival post-TAVI, but significant quality of life gains are observed.
- These findings provide crucial insights into expected outcomes for TAVI patients with complex health profiles.
- Palliative care utilization was low (4.7%) and varied widely across treatment centers.
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