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Systematic review and pharmacological insights of ginsenoside Rf: Current status and future perspectives
Ping Li1, Li-Chun Zhao2, Yin-Shi Sun1
1College of Chinese Medicinal Materials, Jilin Provincial International Joint Research Center for the Development and Utilization of Authentic Medicinal Materials, Jilin Agricultural University, Changchun 130118, China.
Background:
Ginsenoside Rf (Rf), a protopanaxatriol-type saponin mainly found in Panax ginseng C.A. Meyer has drawn significant attention in recent years due to its diverse pharmacological activities.
Purpose:
This review aims to systematically consolidate current knowledge on Rf, focusing on its structural features, content quantification methods, and isolation and purification techniques, delving into its wide-ranging pharmacological actions.
Methods:
Relevant keywords were used to search databases such as PubMed, Web of Science, ScienceDirect, and CNKI to collect and integrate Rf-related research data.
Results:
Through summarizing the existing research progress, we found that Rf has pharmacological effects such as neuroprotection, cardiovascular regulation, analgesia, anti-inflammation, immunomodulation, antitumor activities, and metabolic regulation. This mini-review also delves into the pharmacokinetics of Rf and the potential for future studies, intending to offer a comprehensive insight into Rf and its possible application in medical and pharmacological domains.
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