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Updated: Jan 14, 2026
Imaging Analysis of Neuron to Glia Interaction in Microfluidic Culture Platform MCP-based Neuronal Axon and Glia Co-culture System
Published on: October 14, 2012
Decoding the Hex-GM2-MGL2 axis in microglia-neuron crosstalk
Dennis-Dominik Rosmus1, Bahareh Ajami2
1Institute of Anatomy, Leipzig University, Leipzig, Germany; Cellular Neuroanatomy, Chair of Anatomy and Cell Biology, Institute of Theoretical Medicine, University of Augsburg, Augsburg, Germany; Department of Neurology, University of Leipzig Medical Center, Leipzig, Germany.
Abstract:
Neurodegeneration arises from malfunctional intercellular interactions within the central nervous system (CNS). In a recent study, Frosch et al. identified a microglia-neuron enzyme delivery system the dysfunction of which drives Sandhoff disease, but which can be corrected by hematopoietic replacement therapy, thereby revealing new therapeutic opportunities for hereditary and sporadic neurodegenerative disorders.
