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Related Experiment Video

Updated: Jan 14, 2026

Imaging Analysis of Neuron to Glia Interaction in Microfluidic Culture Platform MCP-based Neuronal Axon and Glia Co-culture System

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Published on: October 14, 2012

Decoding the Hex-GM2-MGL2 axis in microglia-neuron crosstalk.

Dennis-Dominik Rosmus¹, Bahareh Ajami²

¹Institute of Anatomy, Leipzig University, Leipzig, Germany; Cellular Neuroanatomy, Chair of Anatomy and Cell Biology, Institute of Theoretical Medicine, University of Augsburg, Augsburg, Germany; Department of Neurology, University of Leipzig Medical Center, Leipzig, Germany.

Trends in Pharmacological Sciences

|October 18, 2025

Summary

Malfunctioning microglia-neuron enzyme delivery systems drive neurodegeneration in Sandhoff disease. Hematopoietic replacement therapy offers a promising treatment for this and other neurodegenerative disorders.

Keywords:

Hexb MGL2 Sandhoff disease gangliosides microglia neurodegeneration

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Last Updated: Jan 14, 2026

Imaging Analysis of Neuron to Glia Interaction in Microfluidic Culture Platform MCP-based Neuronal Axon and Glia Co-culture System

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An Engulfment Assay: A Protocol to Assess Interactions Between CNS Phagocytes and Neurons

An Engulfment Assay: A Protocol to Assess Interactions Between CNS Phagocytes and Neurons

Published on: June 8, 2014

Area of Science:

Neuroscience
Genetics
Immunology

Background:

Neurodegeneration involves impaired communication between central nervous system (CNS) cells.
Sandhoff disease is a fatal neurodegenerative disorder caused by genetic mutations.

Purpose of the Study:

To investigate the role of intercellular communication in neurodegeneration.
To identify therapeutic targets for Sandhoff disease and related disorders.

Main Methods:

Analysis of microglia-neuron interactions in a mouse model of Sandhoff disease.
Evaluation of hematopoietic stem cell transplantation as a therapeutic intervention.

Main Results:

A dysfunctional microglia-neuron enzyme delivery system was identified as a key driver of Sandhoff disease pathology.
Hematopoietic replacement therapy successfully corrected the enzyme deficiency and ameliorated disease symptoms.

Conclusions:

The study highlights the critical role of intercellular enzyme delivery in maintaining CNS health.
Hematopoietic replacement therapy presents a viable therapeutic strategy for Sandhoff disease and potentially other neurodegenerative conditions.