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Molecular Characterization of Pericardial Mesothelioma With Constrictive and Recurrent Pericarditis: TAZ

Ryan Tudino1, Shelby Smith1, Liang Cheng2

  • 1Department of Internal Medicine, Rhode Island Hospital, Warren Alpert School of Medicine at Brown University, Providence, Rhode Island, USA.

JACC. Case Reports
|October 19, 2025
PubMed
Abstract

Insights

Malignant pericardial mesothelioma (MPM) is rare and mimics inflammation. Molecular profiling, including TAZ amplification, aids diagnosis and targeted therapy for BAP1/CDKN2A-negative cases.

Area of Science:

  • Oncology
  • Molecular Pathology

Background:

  • Malignant pericardial mesothelioma (MPM) is a rare, aggressive cancer.
  • Clinical presentation is often nonspecific, mimicking inflammatory conditions.
  • Common genetic markers like BAP1 loss and CDKN2A deletion are not always present in MPM, complicating diagnosis.
Keywords:
cancergene therapypericardial effusionpositron emission tomography

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