Related Experiment Video
Updated: Jan 14, 2026

Author Spotlight: Implementing the Enhanced Recovery After Surgery Concept in Rehabilitation Following Anterior Cruciate Ligament Reconstruction
Published on: March 1, 2024
Simple clinical measures quantify knee loading symmetry during running after anterior cruciate ligament
Benoit Pairot-de-Fontenay1, Jean-Sébastien Roy2, Richard Willy3
1Inter-university Laboratory of Human Movement Biology (LIBM EA 7424), Université Lyon 1, Villeurbanne, France; Ramsay Santé, Clinique de la Sauvegarde, Lyon, France; The Running Clinic, Lac Beauport, Canada.
Objectives:
Knee loading asymmetry is commonly observed during running after anterior cruciate reconstruction (ACL-R). We sought to determine whether clinically measurable asymmetries could predict knee loading symmetry (LSI) during running after ACL-R.
Design:
Longitudinal laboratory study.
Setting:
Three-dimensional running biomechanics.
Participants:
24 participants post-ACL-R and 24 healthy, matched controls.
Main Outcome Measures:
LSI of knee loading variables (patellofemoral and tibiofemoral joint reaction force [PFJRF/TFJRF], and knee negative work) were assessed alongside clinically measurable variables (stance time, peak knee flexion angle, knee flexion excursion and foot strike angle). Assessments were conducted at baseline (D1) in both groups, with the ACL-R group also assessed after a 14-day return-to-run program (D14).
Results:
Peak knee flexion angle LSI significantly predicted PFJRF and TFJRF peak and average loading rate LSIs (all p < 0.01). Knee flexion excursion LSI predicted knee negative work LSI (p < 0.001). The R2 for the predictive equations for PFJRF Average loading rate, PFJRF Peak, TFJRF Peak, TFJRF Average loading rate and Knee negative work were 0.69, 0.75, 0.73, 0.58 and 0.41, respectively.
Conclusions:
Knee joint loading symmetry during running following ACL-R can be estimated using clinically accessible variables. Among these, peak knee flexion angle symmetry emerged as the most promising predictor.
Level Of Evidence:
Longitudinal observational study, level III.
More Related Videos
06:28Anterior Cruciate Ligament Transection and Synovial Fluid Lavage in a Rodent Model to Study Joint Inflammation and Posttraumatic Osteoarthritis
Published on: September 2, 2025
06:27Author Spotlight: Investigating Early Events and Long-Term Effects of ACL Injuries for Osteoarthritis Progression
Published on: September 29, 2023