Related Experiment Video
Updated: Jan 14, 2026
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
Prevalence and factors affecting sarcopenia in middle-aged and older adults with knee osteoarthritis: A multicenter
Guangyuan Dong1, Nanyan Li1, Jihua Li2
1School of Nursing, Southern Medical University, Guangzhou, Guangdong, China.
Objective:
To investigate the prevalence of sarcopenia in middle-aged and older adults with knee osteoarthritis (KOA) and to analyze its influencing factors.
Methods:
A cross-sectional survey was conducted on 435 patients with KOA from three general hospitals in Guangdong Province, China. Patients with sarcopenia were identified according to the 2019 criteria of the Asian Working Group for Sarcopenia (AWGS). Sociodemographic variables, clinical characteristics and body composition were collected. Univariate analysis of variance and binary logistic regression analysis were used to determine the influencing factors.
Results:
The prevalence of sarcopenia among patients with KOA was 21.43%, indicating a considerable burden in this population. Binary logistic regression analysis showed that older age, abnormal calf circumference, higher body fat percentage, higher Kellgren-Lawrence classification, and sedentary behavior were significant risk factors for sarcopenia, while body mass index was identified as a protective factor.
Conclusion:
Sarcopenia is relatively common among patients with KOA, underscoring the importance of greater clinical awareness and prioritization of muscle health in this population. These findings provide important evidence for identifying high-risk individuals and inform future strategies for early recognition and intervention.
More Related Videos
Related Concept Videos
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:09Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...