Modulating metabolism and reproductive health through microbiome driven gut-brain axis therapies

The gut microbiome plays a crucial role in regulating metabolic and reproductive health through the gut-brain axis. This review underscores the therapeutic potential of modulating gut microbiota to alleviate conditions such as obesity and polycystic ovarian syndrome (PCOS). Gut dysbiosis as an imbalance microbiome, has direct effect on insulin resistance, hormonal imbalances, and systemic inflammation. It contributes to metabolic and reproductive disparities. This study reveals the coordination between dysbiosis and obesity, and PCOS. Alterations in gut-microbiota is the major contributor of insulin-resistance, menstrual dysfunction, and hormonal imbalances. It also focuses on the efficacy of probiotic and relevant microbes. Considering the literature, microbiome-potential and its role in treating the interventions is significantly important. Outcomes recommend that gut-dysbiosis aggravates metabolic and reproductive health illnesses by making worse hormonal inequalities and inflammation. The therapy probiotic has indicated favorable outcomes in enhancing insulin-resistance and menstrual cycle regulation, highlighting its capability as a reliable treatment for PCOS and obesity. Nevertheless, well-monitored clinical trials are necessary on large scale to make it optimized microbiome-focused treatments for long-term results and safety.