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High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity
Published on: November 16, 2016
IMPDH as a potential antibacterial drug target for microbial infections: A review on a decade of targeted therapy and
Haritha Dilip1, Shalini1, Vijay Thiruvenkatam2
1Department of Chemistry, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, Gujarat 382055, India.
Abstract:
Infectious diseases of bacterial origin currently account for the greatest number of human deaths worldwide, serving as a major hurdle for the growth of many developing nations including the Indian subcontinent. However, identification of potential therapeutic drug targets in infectious pathogens, to facilitate species-selective and target-specific inhibition for the development of effective therapeutic regimens, involves several challenges ranging from the identification and validation of a suitable drug target to overcoming drug toxicity and antimicrobial resistance. This short review is a compilation of a decade of research on the potential antibacterial drug target inosine-5'-monophosphate dehydrogenase (IMPDH) and its therapeutic implications for microbial infections.
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