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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Association of Influenza Vaccination With Acute Kidney Injury: A Prospective Target Trial Emulation Study
Lin Zhuo1, Baixue Zhang2, Yi Huang3
1Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, People's Republic of China; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, People's Republic of China.
Summary
Influenza vaccination significantly lowers the risk of acute kidney injury (AKI) in older adults by 17%. This study supports using flu shots to prevent kidney complications in seniors.
Area of Science:
- Nephrology
- Immunology
- Public Health
Background:
- Influenza infection can cause systemic damage, including kidney impairment.
- The effect of influenza vaccination on acute kidney injury (AKI) risk is not well-established in large prospective studies.
- Older adults are particularly vulnerable to influenza complications.
Purpose of the Study:
- To assess the association between influenza vaccination and the incidence of AKI in individuals aged 65 years and older.
- To evaluate if influenza vaccination offers protection against kidney-related complications of influenza.
Main Methods:
- A target trial emulation using a sequential design within the UK Biobank cohort.
- Propensity score matching (1:1 ratio) to compare vaccinated and unvaccinated individuals aged 65+.
- Analysis of incident AKI over a 1-year follow-up period, with adjustments for confounders.
Main Results:
- Influenza vaccination was associated with a 17% reduction in AKI risk (HR, 0.83; 95% CI, 0.71-0.98).
- The incidence of AKI was lower in vaccinated individuals (30.6 per 10,000 PYs) compared to unvaccinated (36.8 per 10,000 PYs).
- A significant reduction in mortality was also observed in the vaccinated group (HR, 0.75; 95% CI, 0.66-0.85).
Conclusions:
- Influenza vaccination is significantly associated with a reduced risk of incident AKI in older adults.
- Findings support the use of influenza vaccination to prevent both influenza and its associated kidney complications in the elderly.
- Further research should address potential residual confounding and selection bias.
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