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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
662

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Related Experiment Video

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Combining Transcranial Magnetic Stimulation and fMRI to Examine the Default Mode Network
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Structural-Functional Brain Network Modulation using Transcranial Focused Ultrasound Stimulation: Implications on the

Chang-Hyun Park1, Song E Kim2, Yun Seo Choi3

  • 1Artificial Intelligence Convergence Graduate Program, Ewha Womans University, Seoul, South Korea.

Neuroimage
|October 19, 2025
PubMed
Summary
This summary is machine-generated.

Transcranial focused ultrasound (tFUS) can modulate brain networks. This study found specific excitatory tFUS protocols targeting the medial prefrontal cortex enhance structure-function coupling within the default mode network.

Keywords:
Default mode networkMedial prefrontal cortexNeuromodulationStructure-function correspondenceTranscranial focused ultrasound

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Non-invasive Brain Stimulation

Background:

  • Transcranial focused ultrasound (tFUS) offers precise, deep brain stimulation.
  • Understanding tFUS's network modulation capabilities and optimal parameters is crucial.
  • The medial prefrontal cortex (mPFC) is key to the default mode network (DMN).

Purpose of the Study:

  • Investigate tFUS effects on the DMN by targeting the mPFC.
  • Determine if varying sonication parameters modulates the DMN.
  • Assess tFUS impact on structure-function correspondence within brain networks.

Main Methods:

  • 21 healthy participants received excitatory, suppressive, or sham tFUS targeting the mPFC.
  • Diffusion-weighted MRI and resting-state functional MRI assessed brain connectomes.
  • Changes in structure-function correspondence were compared across groups post-tFUS.

Main Results:

  • tFUS generally increased structure-function coupling near the mPFC after excitatory and suppressive stimulation.
  • Excitatory tFUS significantly enhanced structure-function correspondence within the DMN.
  • The study identified specific tFUS parameters for effective DMN modulation.

Conclusions:

  • Optimized tFUS protocols can effectively modulate the default mode network.
  • Findings provide insights for refining tFUS for brain network interventions.
  • tFUS shows potential as a non-invasive therapeutic tool for neurological conditions.