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Neuroendocrine Hyperplasia of Infancy and Diffuse Idiopathic Neuroendocrine Cell Hyperplasia: Two Faces of Pulmonary
Julie C Worrell1, Helen O'Brien2, Sean Quinn3
1Depratment of Medicine, Conway Institute and School of Medicine, University College Dublin, Ireland D04 C1P1.
Abstract:
Diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH) and neuroendocrine hyperplasia of infancy (NEHI) are rare lung diseases occurring in adults and children, respectively and are characterized by the proliferation of pulmonary neuroendocrine cells. DIPNECH and NEHI are distinct clinical entities with varying clinical presentations and approaches to management. Airway obstruction, possibly caused by dysfunction in neuroendocrine signaling is common across both conditions. Greater understanding of the underlying pathogenesis is needed to develop future treatments in this area.
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