Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chronic neuroinflammation after acute SARS-Cov-2 infection induces retinal damage in the hACE2 transgenic mouse model.

Journal of neuroimmunology·2026
Same author

Corrigendum to 'Pasteurized Akkermansia muciniphila HB05 improves ultraviolet B-induced skin dehydration and barrier dysfunctions in SKH-1 hairless mice' [Biomed. Pharmacother. 200 (2026) 119577].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Immunomodulatory Effects of Bifidobacterium bifidum BGN4 in Cyclophosphamide-induced Immunosuppressed Mice via Activation of NK Cells and Macrophages.

Probiotics and antimicrobial proteins·2026
Same author

Pasteurized Akkermansia muciniphila HB05 improves ultraviolet B-induced skin dehydration and barrier dysfunction in SKH-1 hairless mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

<i>Ledum palustre</i> var. <i>diversipilosum</i> attenuates DNFB-induced allergic contact dermatitis through regulation of NLRP3 inflammasome/IL-1β signaling.

Food science and biotechnology·2026
Same author

Newly isolated human-derived <i>Lactobacillus fermentum</i> strain stimulates IFN-γ-secreting CD8<sup>+</sup> T cells for enhanced anti-cancer immunity.

iScience·2026

Related Experiment Video

Updated: Jan 14, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
07:36

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

7.5K

TF-343 Recovered Cyclophosphamide-Induced Compromised Immune Status in a Mouse Model.

Gun-Dong Kim1, Sang Hyuk Yoo1,2, Kyung Min Lim1,2

  • 1Research Division of Food Functionality, Korea Food Research Institute (KFRI), Wanju 55365, Republic of Korea.

Journal of Microbiology and Biotechnology
|October 19, 2025
PubMed
Summary

TF-343, a plant extract, was studied for its immune-boosting effects in a cyclophosphamide (CP)-induced immunosuppression mouse model. Results show TF-343 effectively restored immune cell counts, proliferation, and function, highlighting its potential as an immunoregulatory substance.

Keywords:
Cyclophosphamideimmune compromised modellymphocytemacrophagenatural killer cell

More Related Videos

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

2.1K
Murine Model of Epicutaneously-Induced Immunomodulation
09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

488

Related Experiment Videos

Last Updated: Jan 14, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
07:36

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

7.5K
Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

2.1K
Murine Model of Epicutaneously-Induced Immunomodulation
09:07

Murine Model of Epicutaneously-Induced Immunomodulation

Published on: June 24, 2025

488

Area of Science:

  • Immunology
  • Pharmacology
  • Natural Product Research

Background:

  • Cyclophosphamide (CP) is a chemotherapeutic agent inducing immunosuppression, utilized in research models.
  • TF-343 is a medicinal plant extract with known anti-inflammatory and antioxidant properties.
  • Understanding TF-343's immunomodulatory potential in suppressed immune systems is crucial.

Purpose of the Study:

  • To investigate the immunomodulatory effects of TF-343 in a cyclophosphamide-induced immunosuppressive mouse model.
  • To elucidate the underlying mechanisms of TF-343's action on immune cell function and cytokine expression.

Main Methods:

  • Mice were treated with cyclophosphamide to induce immunosuppression.
  • TF-343 was administered to assess its impact on body weight, organ indices (thymus, spleen), and blood cell counts.
  • Immune cell proliferation (T and B lymphocytes, splenocytes), natural killer cell and macrophage activity, and cytokine (IL-2, IFN-γ) expression were analyzed.

Main Results:

  • TF-343 administration significantly reversed CP-induced reductions in body weight and organ indices.
  • Immune cell populations (lymphocytes, white blood cells) and immunoglobulin levels were restored by TF-343.
  • TF-343 enhanced splenocyte proliferation, natural killer cell and macrophage function, and upregulated IL-2 and IFN-γ expression.

Conclusions:

  • TF-343 demonstrates significant immunomodulatory effects, restoring immune function in a CP-induced immunosuppressive model.
  • The findings suggest TF-343 has potential as an immunoregulatory agent for enhancing immune responses.