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Related Experiment Video

Updated: Jan 14, 2026

TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application

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Published on: June 8, 2016

Double-Network Bioadhesives from Sustainable Plant Precursors.

Animesh Ghosh¹, Wu X Vicki¹, Jie J Ng¹

¹School of Materials Science and Engineering (MSE), Nanyang Technological University (NTU), Singapore 639798, Singapore.

ACS Applied Materials & Interfaces

|October 20, 2025

Summary

Researchers developed a novel, plant-derived tissue adhesive using lipoate polymerization. This strong, flexible, and self-healing bioadhesive offers a sustainable alternative to sutures and commercial glues.

Keywords:

double network nonmutagenic plant precursors self-healing tissue adhesive

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Area of Science:

Biomaterials Science
Polymer Chemistry
Green Chemistry

Background:

Developing effective, non-toxic tissue adhesives to replace sutures is a significant clinical challenge.
Existing double-network adhesives offer toughness but require further optimization for clinical application.

Purpose of the Study:

To create a novel bioadhesive platform using plant-derived precursors and green chemistry principles.
To evaluate the adhesive strength, toughness, and curing properties of a new lipoate-based formulation.

Main Methods:

Utilized lipoate-based ring-opening polymerization combined with oxidative cross-linkers.
Developed a two-component (2C) formulation with a controlled lag period for application.
Tested adhesion strength, elongation, and self-healing capabilities at physiological temperatures.

Main Results:

The novel bioadhesive demonstrated rapid curing (<30 s) after a 10-minute viscous lag period.
Achieved superior adhesion strength, elongation, and self-healing properties compared to commercial formulations.
Employed plant-sourced synthetic precursors, aligning with green chemistry and sustainable manufacturing.

Conclusions:

The lipoate-based bioadhesive platform represents a significant advancement in tissue adhesion technology.
This formulation offers a promising, sustainable, and high-performance alternative to traditional sutures and existing adhesives.
The study highlights the potential of plant-derived materials in developing advanced biomedical adhesives.