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Updated: Jan 14, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Multifunctional Polyphenolic Nanoparticle-Cross-Linked Aminoglycoside Hydrogels.

Zhan Li¹, Jianhua Zhang¹, Hengjie Zhang¹

¹College of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials, Sichuan University, Sichuan University, Chengdu610065, China.

Biomacromolecules

|October 20, 2025

Summary

This summary is machine-generated.

This study presents a novel hydrogel platform with built-in antioxidant and antibacterial properties for advanced wound care. These multifunctional hydrogels effectively manage wound environments, reduce oxidative stress, and prevent infections.

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Area of Science:

Biomaterials Science
Nanotechnology
Wound Healing

Background:

Multifunctional hydrogels are crucial for wound healing, requiring antioxidant and antibacterial properties to manage the wound microenvironment.
Developing hydrogels with programmable responsiveness and structural integrity for therapeutic needs remains a challenge.

Purpose of the Study:

To engineer a modular and functionally programmable hydrogel platform with integrated antioxidant and antibacterial activities.
To create a hydrogel system capable of modulating the wound microenvironment for enhanced therapeutic outcomes.

Main Methods:

A Schiff base reaction was employed between aldehyde-functionalized polyphenolic nanoparticles and aminoglycoside antibiotics to construct the hydrogel platform.
The resulting nanocomposite hydrogels were characterized for mechanical properties, pH-responsiveness, biodegradability, and biocompatibility.

Main Results:

The developed hydrogels demonstrated excellent mechanical properties, pH-responsiveness, biodegradability, and biocompatibility.
In vitro and in vivo studies confirmed potent antibacterial and antioxidant capabilities, effectively controlling infection and reducing oxidative stress in wound models.

Conclusions:

The modular hydrogel platform offers a versatile strategy for engineering adaptive, multifunctional materials for advanced wound management.
This approach successfully integrates antioxidant and antibacterial functionalities for improved wound healing outcomes.