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Comparative in vivo PET imaging of silica microparticles: shape-dependent blood circulation and short-term

Jan Grzelak1, Martí Gich1, Rafael T M de Rosales2

  • 1Institute of Materials Science of Barcelona (ICMAB-CSIC), Campus of the UAB, 08193 Bellaterra, Spain. jpellico@icmab.es.

Dalton Transactions (Cambridge, England : 2003)
|October 20, 2025
PubMed

Insights

Silica rods and spheres, particles bridging nano and micro scales, show distinct in vivo biodistributions in mice. This highlights the potential for shape-dependent targeting in drug delivery systems.

Area of Science:

  • Biomaterials science
  • Nanotechnology
  • Pharmacology

Background:

  • Particles at the nanometric-micrometric interface offer combined advantages of microparticle drug loading and nanoparticle systemic benefits.
  • Investigating the in vivo behavior of these hybrid particles is crucial for advancing drug delivery systems.

Purpose of the Study:

  • To evaluate the in vivo biodistribution of silica rods and spheres (approximately 1 micrometer) in mice.
  • To explore the potential for shape-dependent targeting of these particles.

Main Methods:

  • Utilized Positron Emission Tomography (PET) imaging for in vivo tracking of particles in mice.
  • Synthesized and characterized silica rods and spheres with sizes around 1 micrometer.

Main Results:

  • Silica rods and spheres exhibited different biodistribution patterns within the mice.
  • The observed differences suggest that particle shape influences in vivo distribution.

Conclusions:

  • Particle shape is a critical factor influencing biodistribution in vivo.
  • Silica rods and spheres demonstrate potential for shape-specific targeting in biomedical applications.

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