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Updated: Jan 14, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
Published on: January 31, 2025
Paradoxical role and therapeutic potential of autophagy in lymphomas
Qian-Qian Yu1, Chuyun Quan2, Yijing Li3
1Department of Tumor Biobank, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, China.
Abstract:
Lymphomas represent a group of haematological malignancies characterized by heterogeneous clinical outcomes. For patients with relapsed/refractory disease, pathogenesis remains incompletely understood, and therapeutic options pose significant challenges. Accumulating evidence indicates that autophagy is intricately linked to lymphocyte development and lymphomagenesis. As a fundamental metabolic process maintaining cellular survival and tissue homeostasis under starvation or stress, autophagy exhibits context-dependent roles in lymphoma, either promoting or suppressing tumorigenesis in response to diverse therapies. This review synthesizes recent advances in autophagy mechanisms and regulation, their implications for lymphoma and the therapeutic exploitation of autophagy for lymphoma treatment strategies.
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