Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SF3A3 in Liver Hepatocellular Carcinoma: Oncogenic Role and Prognostic Significance.

Oncology·2026
Same author

Neonatal Kasai portoenterostomy for biliary atresia: Clinical characteristics and outcomes.

Journal of pediatric surgery·2026
Same author

Exploring the feasibility of a web-based positive psychology program among anaesthesiologists: an explanatory sequential mixed-methods pilot study.

BMC medical education·2026
Same author

Single-cell transcriptomics reveals anti-inflammatory effects of prednisolone on the hepatic niche in biliary atresia.

Scientific reports·2026
Same author

Experimental Study on the Influence of Different Loading Weights and Placement Forms on Vacuum Sublimation-Rehydration Thawing of Large Yellow Croaker.

Foods (Basel, Switzerland)·2026
Same author

HCMV infection disrupts barrier functions and promotes epithelial-mesenchymal transition in a cholangiocyte organoid model.

Nature communications·2026
Same journal

Analysis of Second Primary Tumours in Cutaneous Lymphoma Populations.

Cancer investigation·2026
Same journal

The Heterogeneity of B Cells Potentially Contributes to Metastasis of Clear Cell Renal Cell Carcinomas.

Cancer investigation·2026
Same journal

The Association Between Lymphocyte-Monocyte Ratio, Tumor-Infiltrating Lymphocytes, and Tumor-Associated Macrophages with 3-Year Progression-Free Survival in Advanced Local Stage Nasopharyngeal Cancer Patients.

Cancer investigation·2026
Same journal

<i>In Vivo</i> Pharmacokinetics, Bio-Distribution and anti-Tumor Activity of Docetaxel-Loaded Folate Targeted Biocompatible Polymeric Micelles.

Cancer investigation·2026
Same journal

Bispecific Antibodies in Multiple Myeloma: A Concise Review of Current Treatments.

Cancer investigation·2026
Same journal

Adrenal Carcinoma Laterality is of Limited Clinical Significance: A National Perspective.

Cancer investigation·2026
See all related articles

Related Experiment Video

Updated: Jan 14, 2026

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

2.1K

BMP2 Pan-Cancer Analysis in Multiple Tumor Types of TCGA Datasets.

Fangran Liu1, Paul David Blakeley1, Ka Chun Wu2

  • 1Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Cancer Investigation
|October 20, 2025
PubMed
Summary
This summary is machine-generated.

Bone morphogenetic protein 2 (BMP2) plays a role in cancer development. BMP2 alterations impact patient survival and may serve as a therapeutic target, particularly through TGF-β signaling.

Keywords:
BMP2TCGATGF-β pathwaybiomarkerpan-cancerprognosis

More Related Videos

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.5K
Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

850

Related Experiment Videos

Last Updated: Jan 14, 2026

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

2.1K
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.5K
Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
09:01

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

850

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Bone morphogenetic protein 2 (BMP2) is crucial for bone development and repair.
  • The specific role of BMP2 in cancer initiation and progression is not fully understood.

Purpose of the Study:

  • To investigate the expression patterns, prognostic significance, genetic alterations, immune infiltration, and signaling pathways associated with BMP2 across various cancer types.
  • To explore the potential of BMP2 as a biomarker and therapeutic target in oncology.

Main Methods:

  • Utilized The Cancer Genome Atlas (TCGA) database.
  • Employed bioinformatic analyses to assess BMP2 expression, genetic alterations, immune cell infiltration, and pathway involvement.
  • Correlated BMP2 status with patient survival outcomes (overall survival and disease-free survival).

Main Results:

  • BMP2 expression was elevated in specific cancers like cholangiocarcinoma and glioblastoma, but decreased in others.
  • High BMP2 expression correlated with poorer survival in several cancers, including esophageal carcinoma and liver cancer.
  • BMP2 mutations and amplifications were observed in lymphomas and endometrial cancer. BMP2 expression was linked to cancer-associated fibroblast infiltration and the TGF-β signaling pathway.

Conclusions:

  • BMP2 exhibits distinct prognostic implications across different tumor types.
  • BMP2 alterations and expression levels suggest its potential as a biomarker for specific cancers.
  • Modulating BMP2 activity, potentially via TGF-β signaling, could offer a therapeutic strategy for certain malignancies.