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Enabling technology for accelerated discovery of supramolecular materials
C E Shields1, A M Scholes1, A G Slater1
1Department of Chemistry and Materials Innovation Factory, University of Liverpool UK anna.slater@liverpool.ac.uk.
Chemical Science
|October 20, 2025
Summary
Organic supramolecular materials offer versatile solutions but face production challenges. Enabling technologies like high-throughput screening and automation can accelerate their discovery and application.
Area of Science:
- Materials Science
- Chemistry
Background:
- Organic supramolecular materials are modular and tunable due to weak intermolecular forces.
- These materials hold promise for applications in separations, storage, sensing, and catalysis.
- Current production methods lack reproducibility, scalability, and sustainability, hindering real-world translation.
Purpose of the Study:
- To explore how enabling technologies can overcome limitations in supramolecular material production.
- To discuss recent advances and future opportunities for accelerated discovery and optimization.
- To bridge the gap between laboratory research and practical applications of supramolecular materials.
Main Methods:
- Review of recent advances in enabling technologies.
- Analysis of the impact of high-throughput screening (HTS), automation, and flow chemistry.
- Discussion of strategies for property tuning and post-synthetic modification.
Main Results:
- Enabling technologies offer pathways to improve reproducibility and scalability.
- Automation and HTS can accelerate the discovery and optimization of supramolecular materials.
- Flow chemistry presents opportunities for sustainable and efficient production.
Conclusions:
- The integration of enabling technologies is crucial for advancing supramolecular materials.
- These technologies can significantly enhance the translation of supramolecular materials from research to industry.
- Future research should focus on leveraging these tools for rapid development and application.

