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Updated: Jan 14, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Beneath the Surface: A Rash That Uncovered Renal Autoimmunity
Matheus Vasconcelos Goes Mendes1, John R Dahl2
1Unidade de Terapia Intensiva (UTI 4), Hospital Português, Salvador, BRA.
Abstract:
We report the case of a 42-year-old male who presented with a generalized rash, acute kidney injury, anemia, and positive antinuclear antibodies (ANA). Serologic testing revealed elevated anti-double-stranded DNA (dsDNA) levels and hypocomplementemia, raising concern for systemic lupus erythematosus (SLE). Kidney biopsy confirmed Class III (focal proliferative) lupus nephritis according to the International Society of Nephrology/Renal Pathology Society 2003 classification. Immunofluorescence demonstrated full-house staining (positive for IgG, C3, C1q, and light chains) with weaker signals for IgA and IgM. Electron microscopy revealed subepithelial and mesangial electron-dense deposits. Early recognition and timely initiation of immunosuppressive therapy led to clinical improvement and stabilization of renal function.
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