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A Case Report of Autoimmune Gastritis Associated With Polyendocrine Syndrome Type III Mimicking Refractory H. pylori
Saki Ubukata1, Hideki Mori1, Tatsuhiro Masaoka1
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, JPN.
Abstract:
A 60-year-old woman had persistent positive urea breath test (UBT) results despite three courses of Helicobacter pylori (H. pylori) eradication therapy. Endoscopy revealed extensive atrophic gastritis with a characteristic "reverse atrophic pattern" affecting the gastric corpus while sparing the antrum. Active H. pylori infection was excluded; however, positivity for anti-parietal cell and anti-intrinsic factor antibodies confirmed autoimmune gastritis (AIG). Further screening identified anti-glutamic acid decarboxylase antibodies and thyroid autoantibodies, leading to a diagnosis of autoimmune polyendocrine syndrome type III. This case highlights the potential for false-positive UBT results in AIG, emphasizing the importance of screening for associated autoimmune conditions.
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