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Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jan 14, 2026

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Published on: March 24, 2023

Late-Onset Isolated Drain Site Metastasis in Colorectal Cancer Managed by a Multidisciplinary Approach.

David Chapman¹, Manaswini Krishnakumar², Adeel Shamim³

¹Family Medicine, Mercy Hospital, Fort Smith, USA.

|October 20, 2025

Summary

A rare case of colorectal cancer (CRC) recurrence at a surgical drain site, with altered microsatellite instability, was successfully treated with resection. This finding suggests potential alternative metastatic pathways in CRC.

Area of Science:

Oncology
Surgical Oncology
Cancer Genomics

Background:

Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide.

Keywords:

colorectal cancer delayed metastasis genomic class switch subcutaneous metastasis tumor seeding

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Advances in genomic prognostication and targeted therapies have improved CRC management.

The surgical management of metastatic CRC, particularly beyond primary tumor resection, requires further investigation.