Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

6.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.9K
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

14.5K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
14.5K
Cancer Therapies02:49

Cancer Therapies

9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
Cancer02:18

Cancer

53.4K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.4K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

437
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
437

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Macrophage-Induced Senescent Cancer-Associated Fibroblasts Promote SASP-Mediated Chemoresistance in Colorectal Cancer.

Cancer research·2026
Same author

Dual role of intratumoral microbiota: From colorectal cancer progression to therapeutic opportunities.

Journal of translational internal medicine·2026
Same author

Unraveling cross-scale driving mechanisms of ecosystem services trade-offs for metropolitan sustainable management: Insight from a three-level hierarchical linear model.

Journal of environmental management·2026
Same author

Circulating Tumor DNA is Associated With Pathologic Response and Survival Outcomes in Patients With Non-Small Cell Lung Cancer Treated With Neoadjuvant Immunotherapy: A Systematic Review and Meta-Analysis.

Archivos de bronconeumologia·2026
Same author

Decoding nucleic acid modification regulatory networks: A key to cancer intervention and treatment.

Physics of life reviews·2026
Same author

Increased precipitation partially alleviates the carbon-water tradeoff under the Grain for Green program.

Environmental research·2026

Related Experiment Video

Updated: Jan 14, 2026

Characterization and Functional Prediction of Bacteria in Ovarian Tissues
10:12

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Published on: October 23, 2021

3.2K

The microbiome in cancer.

Anqi Lin1,2, Minying Xiong2, Aimin Jiang3

  • 1Donghai County People's Hospital (Affiliated Kangda College of Nanjing Medical University) Lianyungang China.

Imeta
|October 20, 2025
PubMed
Summary
This summary is machine-generated.

The human microbiome significantly influences cancer development, immunity, and treatment response. Understanding these microbial roles offers new strategies for cancer prevention and therapy.

Keywords:
cancermicrobiomeprecision oncologytreatmenttumor microenvironment

More Related Videos

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

31.1K
Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells
06:07

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

Published on: June 13, 2020

7.1K

Related Experiment Videos

Last Updated: Jan 14, 2026

Characterization and Functional Prediction of Bacteria in Ovarian Tissues
10:12

Characterization and Functional Prediction of Bacteria in Ovarian Tissues

Published on: October 23, 2021

3.2K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

31.1K
Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells
06:07

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells

Published on: June 13, 2020

7.1K

Area of Science:

  • Oncology
  • Microbiology
  • Immunology

Background:

  • The human microbiome plays a critical role in cancer biology, affecting tumor development, immune responses, and treatment outcomes.
  • Microbial dysbiosis is linked to carcinogenesis through mechanisms like chronic inflammation, metabolic changes, and immune evasion.
  • Organ-specific microbial signatures are emerging as potential non-invasive biomarkers for cancer detection and prognosis.

Purpose of the Study:

  • To provide a comprehensive review of the multifaceted roles of bacteria, viruses, and fungi in cancer.
  • To synthesize evidence on how microbial dysbiosis contributes to cancer development.
  • To explore the impact of the microbiome on cancer therapies and discuss microbiome-targeted strategies.

Main Methods:

  • Systematic review of current scientific literature.
  • Synthesis of evidence on microbial roles in carcinogenesis and cancer immunity.
  • Analysis of the impact of intratumoral microbiota on therapeutic efficacy and resistance.

Main Results:

  • Microbial dysbiosis promotes cancer through inflammation, metabolic reprogramming, genotoxic stress, immune evasion, and epigenetic changes.
  • Organ-specific microbiome signatures show potential as biomarkers for early detection, treatment stratification, and prognosis.
  • Intratumoral microbiota and their metabolites significantly influence cancer therapy efficacy and resistance.

Conclusions:

  • The human microbiome is a key regulator in cancer biology, impacting all stages from development to treatment.
  • Microbiome-targeted strategies, including probiotics and fecal microbiota transplantation, offer promising avenues for adjunctive cancer therapy.
  • Harnessing the microbiome holds transformative potential for cancer prevention and treatment, requiring further investigation.