Related Experiment Video
Updated: Jan 14, 2026

Using an Extracellular Flux Analyzer to Measure Changes in Glycolysis and Oxidative Phosphorylation during Mouse Sperm Capacitation
Published on: January 22, 2020
The role of the pentose phosphate pathway on reproductive functions
José Victor Braga1,2, Janine de Camargo3, Mariana Marques4
1Fisiopatologia e Biotécnicas da Reprodução Animal - FIBRA, Faculdade de Veterinária, Universidade Federal de Pelotas - UFPel, Pelotas, RS, Brasil.
Abstract:
The application of assisted reproductive techniques (ART) in both farm animals and humans has faced challenges since its inception. Advances in this field have largely depended on a deeper understanding of the metabolic requirements and molecular dynamics of sperm, oocytes, and embryonic development. Glucose, for instance, is commonly utilized as an energy source in in vitro procedures. The pentose phosphate pathway (PPP), a pathway parallel to glycolysis, plays a key role in redox regulation via NADPH generation and ribose biosynthesis. This review highlights the role of the PPP in reproductive cells and discusses its potential implications for ART procedures.
Related Concept Videos
Other Glycolytic Pathways
Biosynthesis of Nucleic Acids
Glycolysis
Gonadal and Placental Hormones
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
Glycolysis: Preparatory Phase
Spermatogenesis

