Related Experiment Video
Updated: Jan 14, 2026
11:27
A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn
Published on: April 7, 2023
7.2K
A Structured Approach to Identifying and Addressing Drug Therapy Problems in Neonatal and Pediatric Critically Ill
Braydon Moore1, Peter N Johnson1, Jamie Miller1
1Department of Pharmacy: Clinical and Administrative Sciences (BM, PNJ, JLM), College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Summary
Pharmacy trainees can use the new IN-DEPTH mnemonic to navigate complex pediatric critical care cases. This tool aids in optimizing treatment for critically ill children, enhancing care quality.
Area of Science:
- Pediatric Critical Care Pharmacy
- Clinical Pharmacy Practice
- Medication Management
Background:
- Pediatric critical care presents unique challenges for pharmacy trainees due to complex patient factors and medication regimens.
- Existing tools like FASTHUG MAIDENS are validated for adult critical care but not pediatric settings.
- A structured approach is needed to support trainees in this specialized field.
Purpose of the Study:
- To introduce the IN-DEPTH mnemonic, a novel tool for pharmacy trainees and practitioners.
- To provide a framework for evaluating critically ill pediatric patients.
- To identify opportunities for optimizing medication therapy in pediatric critical care.
Main Methods:
- Development of the IN-DEPTH mnemonic tailored for pediatric critical care.
- Inclusion of rationale and examples for each component of the mnemonic.
- Focus on enhancing the understanding and application of the tool for trainees.
Main Results:
- The IN-DEPTH mnemonic offers a structured approach to patient evaluation.
- It aims to build confidence and competence in less experienced practitioners.
- The tool facilitates identification of areas for treatment optimization in pediatric critical care.
Conclusions:
- The IN-DEPTH mnemonic serves as a valuable educational and practical resource for pharmacy trainees.
- It addresses the gap in specialized tools for pediatric critical care pharmacy.
- Implementation of IN-DEPTH can lead to improved patient care and outcomes.
Related Concept Videos
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
209
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
209
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
251
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
251
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
241
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
241
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
191
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
191
01:29Drug Dosing: Infants and Children
250
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
250
01:21Factors Affecting Drug Response: Overview
3.0K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
3.0K