The mechanism of m6A modification in cardiovascular diseases: A systematic review

Area of Science:

• Molecular Biology
• Epigenetics
• Cardiovascular Research

Background:

• N6-methyladenosine (m6A) is a key RNA epigenetic modification.
• Cardiovascular diseases (CVDs) are a leading global cause of mortality.
• m6A RNA modifications are increasingly recognized for their role in CVD pathogenesis.

Purpose of the Study:

• To review the role of m6A RNA modifications in various cardiovascular diseases.
• To discuss the regulatory mechanisms and interactions of m6A enzymes in CVD.
• To explore m6A as a potential target for CVD diagnosis and treatment.

Main Methods:

• Literature review of m6A RNA modifications in cardiovascular disease.
• Analysis of regulatory processes involving m6A methyltransferases and demethylases.
• Synthesis of current understanding of m6A's molecular mechanisms and biological functions in CVD.

Main Results:

• m6A modifications significantly influence the initiation and progression of CVDs.
• Interactions of m6A regulatory components can either promote or inhibit CVD.
• m6A levels are dynamically regulated by methyltransferases and demethylases in CVD contexts.

Conclusions:

• m6A RNA methylation represents a critical factor in cardiovascular disease development.
• Targeting m6A pathways may offer novel strategies for CVD diagnosis and therapy.
• Further research into m6A's molecular mechanisms is essential for clinical translation in CVD.