The Application of Exosomes From Different Sources Loaded with Natural Small-Molecule Compounds in Disease

Area of Science:

• Biotechnology
• Nanomedicine
• Pharmacology

Background:

• Exosomes are nanoscale vesicles with inherent biological functions ideal for drug delivery.
• Natural compounds offer therapeutic potential but face challenges like poor solubility and rapid clearance.
• Exosomes can overcome these limitations, improving drug stability, bioavailability, and targeting.

Purpose of the Study:

• To review the application of exosomes from various sources for delivering natural compounds in disease treatment.
• To discuss the dual role of exosomes as carriers and therapeutic agents.
• To explore strategies for enhancing natural compound utilization and developing targeted nanomedicines.

Main Methods:

• Literature review of studies on exosome-mediated delivery of natural compounds.
• Analysis of exosome bioactivity, targeting specificity, and regulatory effects.
• Discussion of integrated exosome-natural compound therapeutic strategies.

Main Results:

• Exosomes effectively enhance the stability and bioavailability of natural compounds.
• Exosomes enable targeted delivery of natural compounds to specific disease sites.
• Exosomes possess intrinsic therapeutic properties, complementing the delivered compounds.

Conclusions:

• Integrating exosomes with natural compounds offers a promising strategy for targeted nanomedicine.
• Exosomes serve dual roles as drug carriers and therapeutic agents, enhancing treatment efficacy.
• This approach holds potential for novel therapeutic strategies against various diseases.