Related Experiment Video
Updated: Jan 14, 2026

LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation
Published on: January 24, 2025
Bacteriophage-mediated antibacterial and photodynamic therapies
Rui Yu1,2,3, Guo-Bo Li4, Bengui Ye4,5
1Key Laboratory of Biodiversity and Environment on the Qinghai-Tibetan Plateau, Ministry of Education, School of Ecology and Environment, Tibet University Lhasa 850000 China xhy78@whu.edu.cn xiaoyl@whu.edu.cn.
Abstract:
Antimicrobial resistance threatens global health, with multidrug-resistant pathogens causing millions of deaths annually. Conventional antibiotics face limitations due to bacterial biofilms, resistance mechanisms, and host toxicity. Bacteriophages, due to their high specificity, hold great potential in antimicrobial therapy, targeted drug delivery. In recent years, advances in chemical biology and nanomaterials science have led to the continuous refinement of surface chemical modification strategies for bacteriophage capsids, providing robust support for their functional expansion. This review summarizes commonly employed bacteriophage surface modification techniques, including both covalent and non-covalent approaches, and categorizes various types of photosensitizers along with their recent progress in antimicrobial applications. Furthermore, it highlights recent studies on bacteriophage-photodynamic synergistic therapy systems in treating bacterial infections and discusses their application prospects and future directions in the field of precision antimicrobial therapy.
Related Concept Videos
Lytic Cycle of Bacteriophages
DNA Bacteriophages
Biological Methods for Microbial Control
Physical Methods for Controlling Microbial Growth: Radiation and Filtration
Microorganisms in Medicine and Therapeutics
Lysogenic Cycle of Bacteriophages

