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Early Neonatal Death in Harlequin Ichthyosis: A Case Report and Literature Review
Ahmed Alanzi1, Dawood Alatefi2, Malik Alkabazi3
1Anaesthesia and Pain Management Department King Hamad University Hospital Muharraq Bahrain.
Clinical Case Reports
|October 20, 2025
Abstract:
Harlequin ichthyosis is a rare, life-threatening neonatal disorder often mistaken for collodion baby. We report a 37-week neonate with severe ectropion, eclabium, and thick fissured scales who died on Day 2 despite optimal care. This case highlights the diagnostic challenges, intensive management needs, and poor prognosis of Harlequin ichthyosis.
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