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Updated: Jan 14, 2026

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Humic acid as a natural catalyst for C-S bond construction: decarbonylative and decarboxylative thioether synthesis
Maral Salehi1, Najmeh Nowrouzi1, Mohammad Abbasi1
1Department of Chemistry, Faculty of Nano and Bio Science and Technology, Persian Gulf University Bushehr 75169 Iran nowrouzi@pgu.ac.ir abbassi@pgu.ac.ir.
Abstract:
In this study, humic acid is introduced as a sustainable and green catalyst for C-S bond formation. Thioethers were synthesized via the reaction of thiols with aldehydes and carboxylic acids in dimethylformamide (DMF), where humic acid effectively facilitated the generation of stable thiyl and alkyl radicals. This method offers a mild, efficient, and environmentally friendly approach with broad functional group tolerance, highlighting the potential of humic acid as a practical catalyst in green organic synthesis.
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