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Updated: May 3, 2026

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Naturally occurring human antiglobulins with specificity for E.

R C Williams, R W Griffiths, J D Emmons

    The Journal of Clinical Investigation
    |April 1, 1972
    PubMed
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    Researchers identified anti-gammaE antibodies in human sera using a hemagglutination test. These antibodies were more prevalent in allergic patients and increased after desensitization, suggesting a role in allergic responses.

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    Area of Science:

    • Immunology
    • Allergy Research

    Background:

    • Human immunoglobulin E (gammaE) plays a role in allergic reactions.
    • The presence and function of antibodies against gammaE (anti-gammaE) in human serum are not fully understood.

    Purpose of the Study:

    • To investigate the prevalence and characteristics of anti-gammaE antibodies in human sera.
    • To explore the potential role of anti-gammaE antibodies in allergic disorders and desensitization.

    Main Methods:

    • Tanned cell hemagglutination test was employed to detect anti-gammaE antibodies.
    • Serum samples from hospitalized patients and individuals with allergic disorders were analyzed.
    • Gradient and gel filtration were used to characterize the antibody type.
    • Leukocyte histamine release assays were performed to assess antibody function.

    Main Results:

    • Anti-gammaE antibodies were detected in 8.5% of general patient sera and 53% of allergic patients.
    • Antibody titers increased in some patients after allergen desensitization.
    • Anti-gammaE antibodies were identified as 19S gammaM macroglobulins.
    • These human anti-gammaE antibodies did not induce histamine release or block allergen-specific histamine release from leukocytes.

    Conclusions:

    • Anti-gammaE antibodies are present in human sera, particularly in individuals with allergic conditions.
    • The observed increase post-desensitization suggests a dynamic immune response involving anti-gammaE antibodies.
    • Despite their presence, human anti-gammaE antibodies do not appear to mediate immediate hypersensitivity reactions via histamine release.