Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

770
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
770
Aging01:26

Aging

587
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
587
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.3K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.3K
Neuron Structure01:30

Neuron Structure

17.8K
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to...
17.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Preoperative Posterior Cingulate Cortex Microstructural Damage With Postoperative Delirium.

Anesthesia and analgesia·2026
Same author

A Roadmap to Navigate the Future of Neural Engineering.

Journal of neural engineering·2026
Same author

Contributions of Gray Matter Microstructure to Differences in Fluid Cognition and Episodic Memory Across the Healthy Adult Lifespan.

Human brain mapping·2026
Same author

From cradle to cortex: An exposome- and equity-centered perspective of neurocognitive aging and dementia risk in the era of climate change.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Imaging iron in the brain: solving the puzzle of brain iron, systemic iron, cerebral blood flow, and cognition.

European radiology·2026
Same author

Higher spatial resolution diffusion-weighted imaging improves characterization of white matter disconnection in Alzheimer's disease.

Imaging neuroscience (Cambridge, Mass.)·2026

Related Experiment Video

Updated: Jan 14, 2026

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.5K

High-resolution structural connectivity mediates age-related differences in functional connectivity and fluid

Jenna L Merenstein1,2, Allen W Song2,3, David J Madden2,4

  • 1Department of Psychology, University of Utah, Salt Lake City, UT 84112, USA.

Brain Communications
|October 20, 2025
PubMed
Summary

High-resolution diffusion-weighted imaging better reveals age-related white matter changes impacting brain function and cognition compared to standard methods. This advanced technique enhances understanding of cognitive decline across the adult lifespan.

Keywords:
diffusion-weighted imaginggraph theoretical analyseshealthy agingmultiplexed sensitivity encodingwhite matter

More Related Videos

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.1K
Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

15.6K

Related Experiment Videos

Last Updated: Jan 14, 2026

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
09:01

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance

Published on: May 7, 2014

10.5K
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

14.1K
Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

15.6K

Area of Science:

  • Neuroimaging
  • Cognitive Neuroscience
  • Human Lifespan Studies

Background:

  • Age-related cognitive decline is linked to white matter degradation.
  • Higher resolution diffusion-weighted imaging may offer more precise white matter connectivity estimates than standard resolution.

Purpose of the Study:

  • Compare age-related white matter structural connectivity differences using standard vs. high-resolution diffusion-weighted imaging.
  • Assess the ability of these measures to explain age-related functional connectivity and cognitive changes.

Main Methods:

  • Cross-sectional study of 140 healthy adults (ages 18-88).
  • Acquired standard and high-resolution diffusion-weighted imaging and resting-state functional MRI.
  • Assessed cognition (memory, executive function, perceptual-motor speed) and connectivity using graph theory.

Main Results:

  • High-resolution imaging showed greater age-related decreases in sensorimotor, ventral attention, and sub-cortical networks.
  • Age-related functional connectivity decline was mediated by high-resolution structural connectivity in the default mode network.
  • High-resolution imaging uniquely mediated age-related fluid cognition decline via within-network connectivity.

Conclusions:

  • High-resolution diffusion-weighted imaging better captures age-related white matter changes.
  • These changes constrain age-related alterations in brain function and cognitive performance.
  • Findings highlight the importance of imaging resolution for studying cognitive aging.