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Metabolic Labeling of Leucine Rich Repeat Kinases 1 and 2 with Radioactive Phosphate
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Alkyne-tagged ribitol-5-phosphate derivatives for metabolic labelling of alpha-dystroglycan
Lloyd D Murphy1, Saeed Akkad1, Angelo Lopez1
1York Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, University of York York YO10 5DD UK lianne.willems@york.ac.uk.
RSC Chemical Biology
|October 20, 2025
Abstract:
The glycoprotein α-dystroglycan is essential in establishing cell-matrix interactions and is implicated in the pathology of muscular dystrophies. Novel tools are needed to study its rare and intriguing O-mannosyl glycans. This report describes the synthesis and evaluation of alkyne-tagged ribitol-5-phosphate derivatives for the metabolic labelling of α-dystroglycan in mammalian cells.

