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GPR17 in Glioblastoma: Structure, Ligand Interactions, and Therapeutic Targeting
Ramalakshmi Satyanarayana1, Sree Somala Chaitanya2, Iswarya Suresh Kumar2
1Faculty of Clinical Research, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu 600116, India.
ACS Omega
|October 20, 2025
Summary
G protein-coupled receptor 17 (GPR17) is vital for myelination and neuroprotection. Targeting GPR17 shows therapeutic promise for glioblastoma, a brain cancer where it is overexpressed and drives tumor growth.
Area of Science:
- Neuroscience
- Oncology
- Molecular Biology
Background:
- G protein-coupled receptor 17 (GPR17) is a GPCR involved in cellular signaling.
- It is expressed in the brain, immune cells, and particularly oligodendrocytes, impacting myelination.
- GPR17 plays roles in neuroprotection and inflammation.
Purpose of the Study:
- To review the structure, ligands, and signaling pathways of GPR17.
- To explore GPR17's role in glioblastoma progression and its potential as a therapeutic target.
- To integrate current findings on GPR17 biology and its translational relevance in oncology.
Main Methods:
- Literature review consolidating current research findings.
- Analysis of GPR17's sequence and structural features.
- Examination of GPR17's involvement in glioblastoma and associated signaling.
Main Results:
- GPR17 is overexpressed in glioblastoma, promoting tumor progression and invasion.
- Understanding GPR17 interactions is key for developing targeted therapies.
- GPR17 is implicated in myelin degradation, neuroinflammation, and immune dysregulation.
Conclusions:
- GPR17 is a significant therapeutic target for glioblastoma.
- Further research into GPR17 pathways can inform treatments for neurological and immune disorders.
- GPR17 biology offers translational relevance in oncology and neuroscience.
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