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Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
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Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

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Assessment of cardiac function and left ventricular dyssynchrony in patients with ANCA-associated vasculitis using

Murat Demirci1, Beste Özben1, Ebru Aşıcıoğlu2

  • 1Department of Cardiology, Marmara University, Pendik Training and Research Hospital, Istanbul, Turkey.

Postepy W Kardiologii Interwencyjnej = Advances in Interventional Cardiology
|October 20, 2025
PubMed

Insights

Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis patients show subclinical cardiac dysfunction. Speckle-tracking echocardiography revealed impaired left and right ventricular function and increased left ventricular dyssynchrony, highlighting the need for cardiac monitoring.

Area of Science:

  • Cardiology
  • Rheumatology
  • Immunology

Background:

  • Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a systemic autoimmune disease.
  • AAV can lead to subclinical cardiac involvement, increasing patient morbidity and mortality.

Purpose of the Study:

  • To evaluate subclinical myocardial dysfunction in AAV patients using speckle-tracking echocardiography (STE).
  • To assess left ventricular (LV) and right ventricular (RV) function, and LV dyssynchrony in AAV patients.

Main Methods:

  • 39 AAV patients and 44 healthy controls underwent standard transthoracic echocardiography.
  • STE was used to evaluate LV and RV strain parameters, including global longitudinal strain (GLS).
  • LV dyssynchrony was assessed by peak systolic dispersion (PSD).

Main Results:

  • AAV patients exhibited significantly reduced LV GLS and increased LV PSD compared to controls.
  • Impaired RV strain parameters, including RV GLS and RV free wall strain, were observed in AAV patients.
  • Multivariable regression confirmed AAV presence was independently associated with LV GLS and LV PSD.

Conclusions:

  • STE detected subclinical impairments in LV and RV function in AAV patients, even with normal ejection fraction and no overt symptoms.
  • These findings underscore the importance of cardiac monitoring in AAV patients to detect early cardiac involvement.
  • Speckle-tracking echocardiography is a valuable tool for assessing cardiac function in AAV.
Abstract

Keywords:
ANCA-associated vasculitisglobal longitudinal strainleft ventricular dyssynchronyleft ventricular functionspeckle-tracking echocardiography

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