Unveiling the Therapeutic Potential of 8-Hydroxyquinoline: A Multi-Targeting Approach

In recent years, extensive research has been conducted by medicinal and organic chemists on derivatives of 8-Hydroxyquinoline (8-HQ) due to their potential as therapeutic agents for a wide range of diseases and disorders. These derivatives show promise in treating conditions such as cancer, HIV, tuberculosis, and neurodegenerative disorders. Additionally, the ability of 8-HQ to chelate metal ions adds to its value as a scaffold for developing treatments for various diseases. Over the past two decades, significant efforts have been made to create drug molecules based on 8- HQ that exhibit excellent therapeutic potency against different therapeutic targets. Recognizing the significance of 8-HQ in the field of therapeutics, this review provides an overview of its reported therapeutic activity in the literature over the past two decades. The review also addresses the challenges and opportunities in the development of 8-HQ, suggesting future research directions in this area.